This game does have an overall good message though about seeing how far you would go to save someone you love. It all depends on your childs maturity and how much you trust them not to copy some of the actions. I let my 14 year old daughter play it and she absolutely loved it. This game does have quite a dark storyline but it is a fantastic game so if you feel your child is mature enough to play it, let them. The language really isn't that bad compared to other 15 rated games. The violence is pretty much the same as most games now days, but less than games like Call Of Duty. If you want a certain ending you will have to make them kiss, that's all they will do and none of the sex is shown on camera. The sex can be avoided as well simply by not letting two of the characters kiss when given the option. This seems quite bad however all the nudity can be avoided, you just simply choose not to shower with Ethan and Madison. There is bad language, nudity, violence and sex. However, if you feel that your child is immature i wouldn't recommend this game. This game is absolutely amazing, great story line. A fifth grader might not be able to play this. Buy this game for your kid if they are mature. So uhhh yeah its a great game also, check out Detroit Become Human bevause it is made by the same people. There are cries and screams when your son it hit by a car, and when someone cuts off their finger, they cry pretty loudly. It feels so real when a character dies, or when someone that matters in the game dies, because it goes into detail pretty well. For the overall maturity, it get's into detail pretty quick. There are a lot of scenes with naked people, however, it is mainly them in the shower, but there are some sexual scenes, where Madison ( your character ) is forced to strip down at gun point ( don't worry, she beats the dudes ass ) and how two people have sex, but just legs and naked male top is shown. Nothing is shown but for her beating up the dude :) THre are drugs and alchohol, because your characters with drink every now and then, and one of your characters tales some sort of drug to constantly keep his mind correct, but the drug part is avoidable. However, someone is strapped to a table, with a drill about to go into their hoo ha. It does have quite a lot of death scenes, but gore really isn't present. It's a beautiflly done story about testing how far youll go to save someone you love. ( SPOILERS AHEAD ) Soo, if you cry easily you might not make it through this game.
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The chapters on the history of pizza and different regional styles is a great read, and very informative. I have the hardback, have read 90% of it and used several recipes. I really love this book! It is one of the best cookbooks I have ever bought. I received this book for free from in exchange for my honest review. Overall, if you're in to making pizza (or you'd like to start) this one would be a good one to pick up. A lot of the recipes look really good, and I liked how many different styles of pizzas are included (I also like the simple sauce recipes, which I'd like to try). There's a lot of background information packed into this book, and I think it might be for a person who's slightly more serious about pizza-making (I did skip some of it), although I did find some of the historical information interesting. And since my family actually does make homemade pizza on a pretty regular basis, I thought that this would be a good book to give us some more knowledge and tricks in the making of this blessed gift from Italy. It's the one thing I just can't seem to get enough of, and I can keep up with my three teenage brothers on the amount of it I can eat. I mean, I think most people do, but I just felt the need to admit that I, too, am not immune to the charms of this dish. If you are a pizza lover, I suggest you pick this one up as soon as possible. I just wished I owned this book as I could see myself using this one over and over again. I did get this book from NetGalley for a fair and honest review. The book itself is so detailed and contains wonderful information about pizza and descriptions, I didn't need a pic every single time. Now, there is not a picture for every single recipe but in this case, I'm fine with it. There are a lot of recipes for dough, sauces, and various kinds of pizza. From there, you have chapters on pizza styles (American thin, square, etc), the crust, needed equipment and ingredients, methods, and finally, pizza recipes. The first chapter is 'Soul of a Pizza' where you learn about pizza in Italy in various areas starting with Naples then you move onto the US and how pizza is different in various areas. We have designed two trips we took all around eating pizza. My husband and I have had home-made pizza every Friday for about 15 years. And his innovative, seasonal topping ideas will surprise and delight any pizza lover-and inspire you to create your own signature pies, just the way you like them. His clear, expert instructions will have you shaping pies and loading a pizza peel with the confidence of a professional pizzaiolo. Forkish offers more than a dozen different dough recipes-same-day “Saturday doughs” that you can make in the morning to bake pizza that night, levain doughs made from a naturally fermented yeast starter, and even gluten-free dough-each of which results in the best, most texturally sublime crust you’ve ever made at home. The Elements of Pizza breaks down each step of the pizza-making process, from choosing a dough to shaping your pie to selecting cheeses and toppings that will work for your home kitchen setup. “If there were ever to be a bible for all things pizza-and I mean all things-Ken Forkish has just written it.”-Marc Vetri, author of Mastering Pasta and owner of Vetri The James Beard and IACP Award-winning author of Flour Water Salt Yeast and one of the most trusted baking authorities in the country proves that amazing pizza is within reach of any home cook. It’s hard to imagine a world without Cosmo’s and there seems to be no slow-down in the cocktail’s popularity. It brings about respect and creates an air of sophistication which is hard to beat or to ignore. It’s tough not to be impressed by someone ordering a cocktail which says, “I am cosmopolitan”. Classic cocktails demand new respect since our renewed interest in artisanal pursuits such as craft beers and spirits. No one feels embarrassed ordering it (compared to an earthquake, a pussy foot or a screwdriver). The key to its phenomenal success may also be in its name. With its pink neon glow, it not only looks attractive in a glass, but also bursts with agreeable fruit flavours. With more than eight decades, after first being sighted, it may very well be one of the most universally ordered mixed drinks in America. Well-known bartender, Gaz Regan, claimed that the international version of the cocktail was created by Toby Cecchini & Melissa Huffsmith-Roth in 1989 at the Odeon restaurant in Manhattan based on a poorly described version of Cheryl Cook’s creation.Īccording to Sally Ann Berk and Bob Sennett, The Cosmopolitan appeared in literature as early as 1993 and derived from New York City. The Original Cosmopolitan Cocktail Once I found out that my name, Neal Murray, was listed in Wikipedia and knowing that my close friends have wanted me to write my story for a long time in my own words, I have now decided to share with you the true story of the birth of the Cosmopolitan Cocktail. This was where Cook got the idea to create a drink that everyone could enjoy but that was also visually stunning in a Martini glass. What overwhelmed Cook was the number of people who ordered Martinis just to be seen with a Martini glass in their hand. Cheryl Cook, bartender at the famous Strand Restaurant in South Beach was credited by historian Gary Regan to have created the cocktail when, in a letter in 1985 or 1986, she told him the story. The popularity of the Cosmo also continued throughout the eighties with many laying claims to have created the cocktail. Caine credited the popularity of cocktails in the 1970’s to the Cosmopolitan being served in fern bars. John Caine, owner of several popular bars in San Francisco, was credited for bringing the Cosmo west from Cleveland. Murry claimed to have added a splash of cranberry juice to a Kamikaze and, when served to the first taster of the cocktail, exclaimed “How cosmopolitan”, which is how the cocktail got its name. In 1934 there also appeared a recipe for a Cosmopolitan Daisy (a variation potentially based on a Kamikaze or Daisy cocktail) in Pioneers of Mixing at Elite.Īnother mention, or possible source, of the popular cocktail is attributed to the gay community from Provincetown in Massachusetts.Īccording to famous bartender Neal Murray, he created the Cosmopolitan in 1975 at the Cork & Cleaver steakhouse in Minneapolis. Louis’ Feast Magazine first noted the mention of a cocktail called The Cosmopolitan in 1927. Considered by many to be a modern cocktail today, St. Finally, junctional adhesion molecule (JAM) proteins also enter the molecular structure of these structures, interacting with important intracellular elements, presumably zonula occludens (ZO), the structure that in turn interacts with actin, to maintain cytoskeletal integrity, and thus to ensure BBB impermeability. The presence of occludin in other areas of the body (gastric epithelium, testis, bone) and its changes in various pathologies suggest that occludin has other undiscovered roles, along with the simple structural role in the TJ component. Occludin, the first transmembrane protein identified at the TJ level, has a high molecular mass and complex structure, its intracellular domains interacting with zonula occludens (ZO) proteins in order to stabilize the TJ. Īmong the many claudin family members, claudin 5, 11, and 12 were reported to be found in the CNS. Forming a zipper-like structure, it regulates intercellular spaces and maintains BBB integrity. In addition, proteins are also associated with zonula adherens that form the adherens junctions formed by proteins such as the platelet-endothelial cell adhesion molecule (PECAM) and vascular endothelial-cadherin, also called cadherin-5. At the intracellular level, scaffolding proteins zona occludin-1 (ZO-1), ZO-2, and ZO-3 establish a link between the abovementioned transmembrane proteins and the actin cytoskeleton. This complex consists of a set of several proteins, the most relevant being the transmembrane proteins (claudin, occludin, and junctional adhesion protein), which, although function independently of each other, work in unison to the effect of joining the plasma membranes of adjacent ECs to seal the paracellular space between them. TJs prevent paracellular diffusion and act as a physical barrier to regulate the movement of ions and other molecules between the peripheral blood flow and brain parenchyma. Brain microvascular ECs (BMECs) have an increased mitochondrial content, a lack of fenestrations, minimal pinocytotic activity, and the presence of an elaborate network of tight junctions (TJ) and adherens junctions (AJ) between cells. At the cerebral level, ECs have distinct characteristics, being more specialized compared to ECs located in other organs. ECs are anchored to the basement membrane by cell adhesion molecules (CAMs), belonging to the classes of selectins, the immunoglobulin superfamily, and the integrin family. This type of endothelial tissue is unique, consisting of flattened cells, closely linked together, lining the inside of the blood vessels. Several cellular components ensure the structural stability of the BBB, with endothelial cells (ECs) representing the central structural element of the barrier. Finally, the currently accepted theories on neurodegeneration in MS are summarized.ġ.1. Subsequently, the authors review the specific alteration of the BBB encountered in different stages of MS, focusing on both the modifications of BBB cells in neuroinflammation and the CNS penetration of immune cells. Firstly, the physiological structure and functions of the BBB as a component of the more complex neurovascular unit are presented. The aim of the current narrative review is to merge the relevant evidence on the role of the BBB in MS pathology in a comprehensive and succinct manner. More specifically, neurovascular unit damage is believed to be involved in the critical process of CNS immune cell penetration, which subsequently favors the development of a CNS-specific immune response, leading to the classical pathological and clinical hallmarks of MS. In recent years, the blood–brain barrier (BBB) has increasingly become the focus of many studies as it appears to be involved in both MS disease onset and progression. A sustained research effort, however, should contribute to a deeper understanding of underlying disease mechanisms, which will undoubtedly yield improved results in drug development. Despite ongoing research and the development of several novel therapies, MS pathology remains incompletely understood, and the prospect for a curative treatment continues to be unpromising in the near future. Over the past decade, multiple sclerosis (MS), a chronic neuroinflammatory disease with severe personal and social consequences, has undergone a steady increase in incidence and prevalence rates worldwide. Usually, around this time, I tend to start looking-not necessarily for the person I’ll end up following, but rather for some slow-moving, half-conscious pedestrian-to sharpen my focus and practice a bit. By now, I’ve come to realize, not sadly, that I’ll never be a runner-at least, not like that-but I still try my best to stay healthy, and this is the third and final component of what the game is all about. At this hour, it’s always type-A young professionals, clad in thigh-high neon shorts, listening to music and daubing at sweat as they jog inexorably past. Once I’ve made it to the Bund, I walk down to Shiliupu, a tourist marina exactly one mile south of the Peace Hotel, which I remember from my first week in town, when I was better about working out. I’ve never been a morning person, despite always feeling more grateful and productive whenever it is I’m able to get up early, and that’s yet another benefit of the game: it keeps me from sleeping in. For the first ten minutes or so, I try to focus on my senses, gradually waking up, documenting five things I can see (the sea anemone-like movement of a group of pensioners practicing tai chi a giant blue container ship dominating the Pudong skyline an otherwise glamorous model crushing the heels of her sneakers, smoking a cigarette, between takes the national flags atop the buildings, still vigilant against foreign claims security cameras everywhere, and I mean EVERYWHERE), four I can hear (a passerby speaking French a public security announcement on East Nanjing Road construction in the distance even, at one point, birds in the trees), three I can touch (the interior lining of my coat the railing on the Bund the flimsy sleeve around my cup), two I can smell (perspiration pollution), and lastly, one I can taste (invariably coffee, so sometimes I’ll opt for something more nuanced and flavorful-a pour-over, say-instead). Stopping traffic, quite literally, in the middle of the road. By then, the street sweepers are finishing up and the photographers have emerged, posing newlyweds, models, and the occasional celebrity or two in the early morning light against the Beaux-Arts facades. I sip slowly, savoring the routine, mentally preparing for the day. So, here's what I do: I purchase a large quadruple latte at ARABICA (the capitalization is theirs, not mine) on Yuanmingyuan Lu, a cobblestone promenade about a stone’s throw from the Bund, then wander around Huangpu till what, on a weekday, would be rush hour, coffee in hand. It’s opened my eyes to lesser-known neighborhoods in the city and, in a few cases, even resulted in new friends. It’s entirely innocent, nothing more than a bit of harmlessly eccentric fun. I keep a record in my journal of all the sessions I’ve been on, and for each entry, the only reference to the person I choose to follow is a brief description of their clothes and features at the start. I don’t have much interest in my subjects themselves, anyway-they’re merely conduits for exploration. This is a parameter I set for myself on one of my first times out, a measure intended to keep me from looking (and feeling) like a creep. There’s only one rule to the game: no women or children. Most importantly, however, it’s a distraction. But at the same time, it demands resourcefulness, spontaneity, a sense of adventure, and stamina (both mental and physical). And that’s precisely what the game is about. For a while, I had been looking for a way out: of the rat race, of a social circle turned stagnant, of America, of myself. I worked for four years at a multinational conglomerate in New York City after college-a humdrum, entry-level position I didn’t love but didn’t hate-and when the opportunity arose to transfer overseas (to Hong Kong, then Shanghai), I didn’t think twice. Which must explain, at least partially, how I came to Shanghai. That’s not wrong, I suppose (at least, not in any ostensible sense), but it makes me sound like a misanthrope, which I’m not. In the years that I’ve been doing this, I’ve never been caught, and I attribute my success to what, from a young age, has been described by those around me as a natural circumspection, a tendency to set myself apart. I go on a few test runs before making my choice. I leave my apartment early and head east toward the Bund, a sort of preliminary constitutional before the real walk begins. Whenever I’m bored on the weekends, I like to play a game. In a security advisory published last Wednesday, Progress Software said the critical vulnerability attack started in May and affected all MOVEit Transfer versions. "An attacker may be able to infer information about the structure and contents of the database in addition to executing SQL statements that alter or delete database elements," the agency said. Cybersecurity and Infrastructure Security Agency on Friday to prioritize application of the Progress Software patch. Tracked as CVE-2023-34362, the vulnerability prompted the U.S. "MoveIT Transfer is used across the US Government as a recommended solution and all of them were vulnerable (and in many cases still are as many orgs haven’t patched yet)," Beaumont wrote on Twitter. The New York Department of Financial Services on Thursday reminded financial organizations to report breaches within 72 hours. None of the three organizations immediately responded to a request for comment. The company's LinkedIn page lists the FBI and major corporations, including JPMorgan Chase Bank and Geico, as customers. MOVEit customers include multiple state governments. Security researcher Kevin Beaumont said the list of organizations that had their data stolen includes multiple U.S. Threat intelligence analyst Germán Fernández on Saturday said he had discovered at least 57 instances of potential compromise with the human2.aspx backdoor, of which 39 were in the United States. organizations so far are less forthcoming. The government of Canadian province Nova Scotia disclosed on Sunday that hackers also breached residents' personal information.ĭisclosures from U.S. Our provider assured us that immediate steps were taken to disable the server." flag carrier said it had been "informed that we are one of the companies impacted by Zellis' cybersecurity incident which occurred via one of their third-party suppliers called MOVEit." Boots said the payroll provider attack affected "some of our team members' personal details. "All Zellis-owned software is unaffected, and there are no associated incidents or compromises to any other part of our IT estate," a company spokesperson said.Īffected clients include British Airways, the BBC and U.K. Known victims include British payroll provider Zellis, which said eight corporate customers were affected. Microsoft said the actor is Lace Tempest, also known as FIN11 or TA505. See Also: Live Webinar | Breaking Down Security Challenges so Your Day Doesn’t Start at 3pmĪ threat actor began exploiting a critical SQL injection vulnerability in MOVEit Transfer on May 27 and in some cases has taken data within minutes of deploying the web shells. Microsoft said an affiliate of the Russian-speaking Clop ransomware-as-a-service gang is behind a rash of attacks exploiting a recently patched vulnerability in Progress Software's managed file transfer product. flag carrier British Airways informed employees that hackers had accessed data via payroll provider Zellis and the MOVEit vulnerability. Automatically remember buddy list positioning when plugging in external monitors (#5583).Added a %messageClasses% keyword to message view styles?, allowing greatly improved CSS selector targetting.Detailed menu bar status is now optional via menu bar xtras (#4532).Multi-state menu bar icon options (#4905).Custom menu bar icons are now preserved when upgrading to a new version of Adium (#6972).Improved Adiumy emoticon text equivalents (#6327).Added an animated transition for contact list sorting (#5633).Horizontal autosizing of the contact list is now more accurate (#6618).Tabs can display the number of unread messages.Improved tab length calculation (#6775).Improved drag & drop behavior with tabs (#2555).Tabs handle overflow better, by showing a “chevron” (») pop-up menu (#12).Tabs can now be oriented vertically or horizontally (#3372).Rewritten tabs using PSMTabBarControl (Kent Sutherland, mentored by David Smith).De ontwikkelaars hebben versie 1.1 naar buiten gebracht met de volgende veranderingen: Summer of Code 2006 Changes: Het uiterlijk is in meer dan twintig talen te gebruiken waaronder het Nederlands. Het programma is verder natuurlijk voorzien van de nodige features, waaronder OTR encryption, tabbed messaging en het kunnen versturen en ontvangen van bestanden. Adium X is een instantmessagingprogramma voor het Mac OS X-platform en is gebaseerd op Gaim waardoor het kan verbinden met de netwerken van AIM, Bonjour, Gadu-Gadu, Jabber, MSN, Novell Groupwise, QQ en Yahoo. Empowering individuals with specific responsibilities helps ensure they’ll keep up with the tasks as much as possible. If planning on cleaning without a professional, start by delegating responsibilities to the family. The best way to maintain the cleanliness of a home throughout this process is by keeping a schedule and doing small things daily to maintain the house. The laborious process of keeping a home on the market cleaned is especially true if the family still lives in the house. All the movement in the home is what builds up dust and dirt. Between photographers, real estate agents, house tours, and open houses, there’s a lot of activity in a home while it’s on the market. Maintaining a clean house during the selling process is never easy. How can I maintain a clean and organized house during the selling process? Here are some top tips from experts in the home organization field that’ll help you create a clutter-free home that buyers will love. Use bookshelves or bins to keep items off the floor, so the room looks inviting and attractive in case the new homeowners want to use the space as a guest room or home office. Encourage your kids to keep their room clean and make bed daily. Put the toys your kids don’t often play with away in storage or boxes in the closet. Declutter your kids’ roomsĬluttered kids’ rooms are inevitable, but it’s not going to be attractive to buyers. Most home buyers are looking for a nice, roomy kitchen they can cook in and enjoy. The more clutter-free your countertops are, the more open your kitchen will look. Use an environmentally friendly cleaner to wipe down countertops and move items you don’t use daily to the cabinets or drawers. The kitchen is a home’s main selling point, so it’s vital to keep your counter space neat and organized. The goal is to show buyers how much space they’ll have for their own clothing when they move into your home. Keep the items you wear every day stored in a dresser away from the closet. Use bins to corral extra items like bags and accessories or remove them completely. Remove excess clothing and shoes that you don’t wear often and make sure everything is hung nicely on the racks. Organize your closetsĬloset space is important to buyers, so make sure yours are clean and organized. While it may feel uncomfortable, it’s an effective way to provide a clean slate to possible buyers so they can imagine themselves and their families moving in once they buy it. Take down your family photos, your children’s drawings, and other items that are extremely personal to you. Remove personal items to create a more neutral home. You want to create a home where buyers can envision themselves living. Some of the most important things you can start with are: Home organizing aims to create a space that creates competition between buyers to help you get the highest asking price. The goal is to leave buyers feeling wowed and to create a space where potential buyers can imagine themselves living. If you’re planning to sell your home, keeping it clean, organized, and decluttered will help during the selling process. Home Organizing Before Selling: Tips from the Experts Player Series Alnico 2 Humbucking (Neck) Shop the top brands at the best prices all while receiving free shipping.M Muziker club +421 258 101 767 English Support Mo-Fr 8:00-16:30 Belgium - All categories Login Register new account 0 0 0 Shopping Cart Discount. #Fender shawn mendes musicmaster for sale free# Based on the short-scale entry-level Musicmaster model, the 24-inch scale guitar features an alder body, C-shaped maple neck, a maple fingerboard with a 9.5 radius and 22 medium jumbo frets, and a six-saddle string-through-body hardtail Strat bridge. Fender Shawn Mendes Musicmaster Floral Solidbody Electric Guitar Features: Created for Canadian singer/songwriter Shawn Peter Raul Mendes.įenders Shawn Mendes Foundation Musicmaster is a unique combination of. Pickups are a Tex-Mex Stratocaster single-coil at the bridge and a Player Series. 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Retailers must tailor their value proposition to meet consumers’ evolving definitionĪs consumers’ equation for determining value evolves, retailers also must consider value “more holistically,” FMI advises. “Younger shoppers are also willing to spend more money to shop in pleasant stores (experience) and are most likely to prioritize ethical considerations (quality), such as fair treatment of employees and sustainability,” according to the report. Likewise, FMI found consumers increasingly are seeking to balance tension between price and convenience with nearly half willing to shop multiple stores to get the best value and a third willing to pay more to avoid shopping multiple stores – a figure that jumps to 50% for millennials. On the flip side, 26% of consumers opt for larger packages for better price per unit and 36% buy high-quality products at a good price. In response, nearly three-quarters of shoppers expressed concern with rising food prices and nearly all of them (94%) have recalibrated their approaches and priorities when deciding how and where to shop and what to eat, according to FMI’s latest update to its US Grocery Shopping Trends 2023 series published yesterday.įor some, higher prices means buying fewer items (31%), looking for more deals (52%) or switching to less expensive store brands (41%) to maximize value in the historic sense of the term – buying more for less, according to FMI.īut the research also found that younger shoppers’ notion of ‘value’ goes beyond price, with many adopting strategies that still allow them to buy products that meet their health, nutrition and ethical values as well as personal priorities and needs, FMI reports.įor example, FMI found 62% of millennials try to minimize food waste (and expenses) by buying only what they need, and 25% say they avoid spending on something that will go to waste – a strategy that “reflects greater intentionality as shoppers consider utility and trade-offs between needs and wants for both themselves and others in their households.” Emulsifiers, stabilizers, hydrocolloidsĭespite a notable slowdown in inflation for food consumed at home in recent months, including a 0.3% drop from February to March, year-over-year inflation for food consumed at home is up 8.4%, according the US Labor Department.Chocolate and confectionery ingredients.
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